Senior Scientist in Translational Pathology, Oncology We are seeking a Senior Scientist to join the Translational Pathology group in Oncology R&D Translational Medicine department, where you will be at the forefront of the evolution of translational science for a global oncology group in AstraZeneca! You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies. At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe! Major Responsibilities and Accountabilities: This role is a lab-based position working in a Good Clinical Practice (GCP) environment. In this role you will be part of the Translational team driving the the successful operations of a GCP lab, using the best available science and technology to execute routine biomarker analysis and interpret and communicate the data as part of a matrix team. Your work will inform clinical decisions for selecting therapeutically relevant doses and schedules, as well as building our understanding of key cancer pathway interactions to guide rational drug combinations. In addition, your work will help define novel mechanisms of resistance to targeted therapies by studying tumours at relapse. Skills and experience: BSc or MSc in Biomedical Science or a relevant scientific discipline. Experience in an NHS or related clinical setting and HCPC registration is highly desirable. Pharmaceutical industry experience is desirable. Strong experience in manual or automated immunohistochemistry (brightfield or fluorescence) Strong experience in microtomy Strong experience working to Good Clinical Practice or ISO15189. Strong experience in development and validation of biomarker assays Experience working with human tissues and tissue-based histopathology methods Knowledge or experience in one or more AZ portfolio areas: tumour drivers and resistance, DNA damage response (DDR), immuno-oncology (IO) and antibody drug conjugates (ADC) Experience of tracking and/or managing human tissues using sample tracking software (e.g. BSI, SAPIO, Azenta etc.) Highly organized and self-motivated with attention to detail. Ability to work independently as well as collaboratively within a team to deliver to projects Strong written and oral communication skills Strong ability to troubleshooting and critically analyse data Desirable/Advantageous – Although training will be given, experience in the following areas would provide a distinct advantage: Previous pharmaceutical industry experience Experience with digital image analysis solutions (e.g. ImageJ, HALO, Visiopharm etc) Skills in developing multiplexed immunohistochemistry or in situ hybridization (ISH) assays Career exposure to the pharmaceutical industry and the drug development process AstraZeneca offers an environment where courage, curiosity, and collaboration thrive. With a vision to eliminate cancer as a cause of death, we unite cutting-edge science with the latest technology to achieve breakthroughs. Empowered at every level, our team is driven by patient outcomes, making bold decisions and taking smart risks. Join us in pioneering collaborative research with an unrivaled scientific community, working inclusively to expedite research in challenging cancers. Ready to make an impact? Apply now and be part of a team dedicated to improving lives through innovative oncology solutions! To find out more: Group site: https://www.astrazeneca.com/ Our social media, Follow us on LinkedIn: AstraZeneca Inclusion & Diversity: https://careers.astrazeneca.com/inclusion-diversity Career site: https://careers.astrazeneca.com/ Date Posted 17-nov.-2025 Closing Date 01-dez.-2025 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.