Senior Scientist in Process Analytical Technology (PAT) - Make a Meaningful Impact on People's Lives! Are you ready to take your career to the next level and make a meaningful impact on people's lives with life-changing medicines? Join our Operations team in Macclesfield as a Senior Scientist and be part of a team where everyone feels a personal connection to the people we impact. At AstraZeneca, our Operations team has a big ambition: to deliver more medicines to patients, quicker and more affordably. We are driven by our commitment to deliver accelerated growth for AstraZeneca and to make people's lives better. In Pharmaceutical Technology and Development (PT&D), within Operations, we are the bridge between brilliant science and innovative medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture. At Global Product Development (GPD) in Gothenburg, a sub-division of PT&D, we focus on the fields of Oral Controlled Release Drug products and Immediate Release Drug Products. You will join a vibrant team that is working on the next generation of medicines and play a key role in the development of new medicinal products. We are currently looking for a Senior Scientist for PAT in our Product and Process Control group to strengthen our capabilities in the development and implementation of enhanced control strategies using the newest technologies to our late phase portfolio. If you have a solid scientific foundation in this domain and the aspiration to grow into an expert, this role offers an excellent fit. What you’ll do As a Senior Scientist, you will design, develop, and deliver high‑quality enhanced control methods by applying expertise in Process Analytical Technology (PAT), chemometrics, and advanced process monitoring and control. Hands‑on laboratory work will be a core part of your role. You will collaborate with cross‑functional project teams, contribute to regulatory documentation, and support digital initiatives that implement innovative monitoring and control tools across continuous manufacturing platforms. You will participate in the development, validation and technical transfer of methods and PAT tools to enable robust product control strategies across Operations. You will also champion a future‑focused, innovative mindset, advancing data science, predictive modelling and simulation, and artificial intelligence to drive digitally oriented approaches. Essential for the role: - BSc, MSc or equivalent in a relevant discipline (chemistry, pharmacy, engineering etc.) with experience in the use of PAT in the Pharmaceutical or Chemical industries and/or postgraduate experience in Academia with a PAT industrial focus. - A strong understanding of key PAT (e.g., NIR, Raman and microwave spectroscopy) - PAT method development experience, implementation and use of multi-variate data analysis/ Chemometrics (MVDA, PCA, PLS) in common software platforms (SIMCA, Python, MATLAB, PLS Toolbox etc.) - Ability to document and present your work concisely and comprehensibly - Strong collaboration, communication, and leadership skills - An understanding of the principles and management of Safety, Health & Environment (SHE) Desirable for the role: - Demonstrated experience of ensuring compliance with operational requirements (GMP, GAMP, Process Safety, Data integrity, Change Control) - Experience of developing control strategies for pharmaceutical commercial manufacturing processes - Basic scripting skills (e.g. Python, Matlab, R) - Experience with digital tools supporting enhanced control strategies (DCS, PAT management system, APC, Multivariate monitoring platform) - Knowledge of pharmaceutical process equipment/technology for continuous processes Why AstraZeneca? We offer an inclusive environment where you can grow your career while making a positive impact on people's lives. Our team is a multigenerational workforce that thrives on curiosity and problem-solving. We are committed to sustainability and leading the way in delivering Lean processes that drive greater efficiency and speed. Are you ready to step up and lead in a fast-paced environment that rewards commitment and offers diverse career opportunities? Join us at AstraZeneca and be part of our journey towards making people's lives better! So, what’s next? Don't miss this opportunity to make a meaningful impact on people's lives – apply now! Date Posted 08-Dec-2025 Closing Date 06-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.