Job Description General Summary: The RWE Associate Director is an integral member of the RWE team who leverages expertise in epidemiology and real-world data to develop fit-for-purpose observational research and to inform internal and external stakeholders on the natural history (NH) of disease and real-world outcomes within their assigned therapeutic area. The RWE Associate Director works cross-functionally to support the execution of observational research across the portfolio. Key Duties and Responsibilities: Independently lead focused/targeted research of epidemiology of specific disease areas, including NH of disease for business development and early development indications Lead data sourcing strategy for early development and early clinical indications to support NH of disease needed for regulators, payers, and clinicians Lead and execute evaluation of available registries and other data sources related to NH and evidence to support clinical endpoints and inclusion/exclusion criteria Determine the potential use of RWE historical control within the clinical development program and the feasibility of obtaining the data required for historical control Lead execution of approved research tactics within assigned indications Develop draft protocol concept and related materials for review and approval by internal scientific review boards Working closely with stakeholders, align RWE research study tactics with functional and disease program goals Contribute to the development of performance metrics and dashboards for RWE projects Represent RWE on relevant GMDA Sub-Teams, Program Teams, or Disease Strategy Teams where studies related to RWE are discussed Represent RWE on cross-functional collaborations and working groups for pipeline product(s) Utilise strong oral communication skills and understanding of Vertex strategies to promote and translate RWD/RWE methods and activities across the company Support and facilitate external research collaborations with key academic partners, consortia, and data vendors Support the development of cross-functional evidence generation planning Provide leadership and mentorship within RWE Contribute to the company's publications strategy via the development of conference abstracts, presentations, and peer-reviewed manuscripts based on the findings of RWE studies Knowledge and Skills: Applied knowledge of relevant RWE regulatory agency guidance and position papers, and the opportunities to use RWE to inform regulatory decision-making Demonstrated ability to design and execute observational research Strong and clear interpersonal communication, presentation, and study management skills Ability to take detailed observational study results and communicate them in a clear, non-technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings Ability to work collaboratively in a constantly changing, diverse, and matrix environment Education and Experience: Proven experience in a similar role is required, preferably following a PhD or an equivalent combination of education and work experience. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.