Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Stanton Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral Fellow candidates. The Stanton Laboratory develops and harnesses advanced bioengineered brain models to identify potential therapeutic strategies, coupling models to AI-driven approaches, while advancing precision medicine approaches and developing technologies for drug delivery to the brain to further facilitate translation. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Research Fellow at the Harvard Medical School. The Post-Doctoral Fellow will develop and leverage next generation 3D iPSC-derived multicellular brain models for analyzing pathologies via multi-omics, drug testing, and AI-coupling. The Post-Doctoral fellow will be situated in the MGH under the guidance and mentorship of Dr. Alice Stanton. Qualifications The ideal candidate should have received (or expect to receive soon) a Ph.D. in Cell Biology, Neuroscience, Bioengineering, or related field. First (or co-first) author of one or more high impact peer-reviewed scientific publications Excellent English verbal and written communication skills Able to work both independently and in a team Expertise in iPSC culture, differentiation, and 3D co-cultures. Expertise in cellular/molecular techniques including scRNAseq, FACS, IHC, ELISA, PCR, and confocal microscopy. Background in neurodegenerative disease modeling, ideally ALS or related pathologies. Expertise in genetic engineering, including designing and optimizing genetic cassettes. Strong analytical skills for phenotypic data interpretation and assay optimization. Excellent organizational, communication, and teamwork abilities in a fast-paced research environment. Preferred Qualifications: Experience with organ-on-chip development and high-content screening in organoids. Experience with drug screening, pharmacology, ADMET profiling. Experience with computational analysis of multi-omic data. Experience with AI frameworks: NLP, GNN, RL, etc. Familiarity with ALS patient cell repositories (e.g., NINDS, MGB). Knowledge of AI frameworks. How to Apply: Please submit your CV, a cover letter detailing your relevant experience and interest in the project and contact information for three references to aestanton@mgh.harvard.edu We look forward to having you join us in advancing the fight against ALS! Additional Job Details (if applicable) Remote Type Onsite Work Location 185 Cambridge Street EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. 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The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. 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