POSTDOC IN RNA MOLECULAR BIOLOGY_030_FM - H/F - Inserm

The Séraphin team working on protein complexes involved in RNA decay is hiring a post-doc to finalize a project on the Control of deadenylation and translation by the CCR4-NOT complex.

The importance of mRNA decay in regulating and finely tuning gene expression is now well established. The CCR4-NOT complex is a multi-subunit assembly, present in all eukaryotes, that plays a primordial role in this control. Indeed, this complex works as the major deadenylase that initiates mRNA decay by shortening their poly(A) tails modulating mRNA decay and translation. Further, the CCR4- NOT complex has been shown to link translation efficiency to mRNA decay. We have recently identified and characterize new protein partners of the human CCR4-NOT complex. The successful candidate will finalize our study of the functions of some of these new partners. This will be investigated using various cutting-edge technologies.

Main activities : Cell culture, Molecular biology, RT-qPCR, Immunoprecipitation, Western blotting, Next-Generation-Sequencing techniques.

Associated activities : Genome-wide data analysis.

Specific Requirements or Constraints : Strong expertise in molecular biology.

Skills/Qualifications : Autonomy, motivation, good communication, good scientific knowledge.

Required Languages : english.